BME 502:  Course Outline/Syllabus

Lecture 1

        Course Overview

        Fundamental concepts

                Structural and Functional Properties of Neurons and Neuroglia

                Signaling and Communication in the Nervous System

                Anatomical and Electrophysiological Techniques

        Readings

                Hille:          Chapter 1

                Nicholls:       Chapter 1

Lecture 2

        Electrical Properties of Neurons I:

                Ionic Basis of the Resting Membrane Potential

                Membrane Permeability and Conductance

                Types of Membrane Channels

                Channel "States": Kinetic Properties

        Readings

                Nicholls:       Chapters        2-3

Lecture 3

        Electrical Properties of Neurons II:

                Passive Membrane Properties

                Membrane Resistance and Capacitance

                Length Constant and Time Constant

        Readings

                Nicholls:       Chapter 5

Lecture 4

        Electrical Properties of Neurons III:

                Influence of Neuronal Morphology on Electrotonic Properties

                Dendritic Branching Patterns

                Electrical Properties of Dendritic Spines

                Role of Neuroglial Cells

        Readings

                Nicholls:       Chapter 6

Lecture 5

        Electrical Properties of Neurons IV:

                Active Conductances: Ionic Basis of the Action Potential

                Ion-Dependent Conductances

        Readings

                Hille:          Chapter 2-3

                Nicholls:       Chapter 4

Lecture 6

        Electrical Properties of Neurons V:

                Pattern Generation and Signal Transformation

                Interaction between Active and Passive Membrane Properties

        Readings

                Hille:          Chapters        4,5

Lecture 7

        Electrical Properties of Neurons V:

                Pattern Generation and Signal Transformation

                Interaction between Active and Passive Membrane Properties

        Readings

                Hille:          Chapters        4,5

Lecture 8

        Synaptic Transmission I:

                Electrical vs Chemical Synaptic Transmission

                Presynaptic Mechanisms of Neurotransmitter Release

        Readings

                Hille:          Chapter 6

                Nicholls:       Chapter 7

Lecture 9

        Synaptic Transmission II:

                Postsynaptic Mechanisms of Chemical Synaptic Transmission

                Excitatory Neurotransmitters of the Central Nervous System

                Modulation, slow synaptic action and second messengers

        Readings

                Hille:          Chapter 6

                Nicholls:       Chapter 10

Lecture 10

        Synaptic Transmission III:

                Inhibitory Neurotransmitters of the Central Nervous System

                Modulation, slow synaptic action and second messengers

        Readings

                Hille:          Chapter 7

                Nicholls:       Chapter 8

Lecture 11

        Synaptic Plasticity                                                    

 

 

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